TY - JOUR A1 - Khalil, Magdy A1 - Maher, Maram A1 - Al-Kader, Maryam A1 - Kamal, Eman T1 - The association between the serum total cortisol as an adrenal response biomarker and severe community-acquired pneumonia Y1 - 2016/1/1 JF - Egyptian Journal of Bronchology JO - Egypt J Bronchol SP - 100 EP - 104 VL - 10 IS - 2 UR - http://www.ejbronchology.eg.net/article.asp?issn=1687-8426;year=2016;volume=10;issue=2;spage=100;epage=104;aulast=Khalil DO - 10.4103/ejb.ejb_84_17 N2 - Introduction The serum total cortisol is a biomarker to adrenal response in stressful conditions including infection. This study aims to estimate the serum total cortisol level in severe community-acquired pneumonia (CAP) and to study its relation to the severity of illness. Patients and methods The study included 50 patients, who with severe CAP were admitted to the ICU of National Institute of Chest Diseases (Embaba), and 20 healthy adults as the control. Ethical approval done by ASU ethical approval team as the paper was taken from masters thesis. The severity of CAP was estimated using pneumonia severity index (PSI) and CURB65 scores. The two groups were subjected to the estimation of serum total cortisol level (8 a.m.) by electrochemiluminescence immunoassay. Results Serum total cortisol level significantly increased in the patient group than in the control group (20.356±11.198 and 15.070±1.384 μg/dl, respectively). Serum total cortisol level was positively correlated with PSI but not with CURB65 score. Conclusion Severe CAP is associated with increased serum total cortisol level compared to normal. Serum total cortisol level was positively correlated with the disease severity as estimated by PSI. ER -