INTERSTITIAL LUNG DISEASES AND LUNG IN SYSTEMIC DISE
Year : 2015  |  Volume : 9  |  Issue : 1  |  Page : 59-63

Pulmonary involvement in juvenile-onset systemic lupus erythematosus patients asymptomatic for respiratory disease


Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt

Correspondence Address:
Eman F Halawa
Department of Pediatrics, Faculty of Medicine, Cairo University, 23 Dr. Naguib Mahfouz Street, Nasr City, Cairo, 11471
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-8426.153620

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Objective The aim of this study was to investigate the presence and frequency of abnormalities in subclinical pulmonary function tests (PFTs) in a group of Egyptian children with juvenile-onset systemic lupus erythematosus (jSLE) asymptomatic for respiratory manifestations. Patients and methods The study enrolled 20 children with jSLE followed up at the Pediatric Rheumatology Clinic, Cairo University. For all patients, pulmonary function testing was performed including measurement of lung volumes and lung flows using spirometry. Lung diffusion testing was performed using the transfer factor of the lung for carbon monoxide (DLCO) utilizing the single-breath method. Findings were correlated with clinical manifestations and lupus disease activity, and assessed using Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores. Results NAmong our study group, musculoskeletal, mucocutaneous, hematologic, renal, and neurological manifestations were the most frequent lupus manifestations throughout the course of disease, occurring in 85, 80, 65, 45, and 35% of the patients, respectively. The mean SLEDAI score was 21.3 ΁ 9.515. Overall, 95% our patients had at least one PFT abnormality within a mean of 4.9 ΁ 1.94 years after disease onset. Diffusion defect was the most frequent defect detected in 14 (70%) patients, restrictive pathology was found in seven (35%) patients, obstructive pathology was found in six (30%) patients, and mixed restrictive and obstructive pathology in one (5%) patient. In terms of the correlation between PFTs and the SLEDAI, DLCO was correlated positively (r = 0.37, P = 0.05) to a high SLEDAI, that is, a diffusion defect was significantly evident in patients with high disease activity even without symptoms. Conclusion Occult pulmonary disease as shown by a PFT occurs frequently in our group of Egyptian patients with childhood-onset systemic lupus erythematosus.


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